From the Catholic Encyclopedia:
"To sum up, the Biblical knowledge of St. Jerome makes him rank first among ancient exegetes. In the first place, he was very careful as to the sources of his information. He required of the exegete a very extensive knowledge of sacred and profane history, and also of the linguistics and geography of Palestine. He never either categorically acknowledged or rejected the deuterocanonical books as part of the Canon of Scripture, and he repeatedly made use of them. On the inspiration, the existence of a spiritual meaning, and the freedom of the Bible from error, he holds the traditional doctrine."
Saint Jerome in his Study, Albrecht Dürer 1514
Four Doctors of the Church, Carlo Braccesco circa
In other art he is shown studying in solitude, often wearing just a simple robe, with only a crucifix and skull in to meditate on. Sometimes he is shown with a lion, who, according to Jerome's medieval hagiography, befriended the saint after having a thorn removed from its paw.
Jerome in his Study, Niccolo Antonio Colantonio c.
The Vulgate was the definitive edition of sacred scripture in the West for well over one thousand years, and was affirmed as the Church's official text at the Council of Trent in the 16th century. The Gutenberg Bible, the first moveable-type print edition of sacred scriptures, was a copy of the Latin Vulgate.